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Bifunctional molecules with antibody mobilization and entry inhibition activity against human immunodeficiency virus
Bifunctional molecules with antibody mobilization and entry inhibition activity against human immunodeficiency virus
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机译:具有对抗人免疫缺陷病毒的抗体动员和进入抑制活性的双功能分子
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摘要
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI's, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein.
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