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Method for isolation and expansion of autologous cancer antigen-specific CD8 + T cells
Method for isolation and expansion of autologous cancer antigen-specific CD8 + T cells
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机译:分离和扩增自体癌抗原特异性CD8 + T细胞的方法
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摘要
Provided is a method for isolating and proliferating autologous cancer antigen-specific CD8 + T cells, and more particularly, a method for selecting an epitope recognized by CD8 + T cells from autologous cancer antigens present in blood of individual cancer patients; and isolating autologous cancer antigen-specific CD8 + T cells by using a peptide of the selected epitope, and a method of massively proliferating CD8 + T cells by using the method. According to the present invention, it is possible to isolate autologous cancer antigen-specific CD8 + T cells by using the peptide of the CD8 T cell epitope of the autologous cancer antigen present in blood of individual cancer patients instead of a heterologous antigen. Therefore, by using T cells recognizing the autologous cancer antigen, it is possible to effectively select and eliminate cancer cells derived from the cancer patient's own cells. Thus, T cells can be applied to treatment and alleviation of cancer diseases without side effects.
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