Calicheamicin-antibody-drug conjugates and methods of use

摘要

The present invention relates generally to leaving group activated calicheamicin molecules. The invention further relates generally to antibody-drug conjugates comprising an antibody directly conjugated to one or more calicheamicin molecules by disulfides. In some other aspects of the disclosure, there is provided a pharmaceutical composition comprising an antibody-drug conjugate of the disclosure, the pharmaceutical composition comprising at least one of a diluent, a carrier, and an excipient. One more. In other embodiments, a pharmaceutical composition comprising an antibody-drug conjugate of the present disclosure, and at least one of a diluent, carrier, and excipient is for administration to a patient for the treatment of cancer. Provided.