A method to help predict prognosis after allogeneic hematopoietic stem cell transplantation

摘要

An object of the present invention is to provide a method for predicting the prognosis after transplantation even when the HLA between the donor and the recipient is partially mismatched in allogeneic hematopoietic stem cell transplantation. Among alleles in allogeneic hematopoietic stem cell transplantation, 1 allele or 2 alleles are mismatched among the 4 alleles of HLA genes HLA-A, HLA-B, HLA-C, and HLA-DRB1 in the HLA gene, and the recipe In the case where the ent is a patient with malignant blood disease (excluding myelodysplastic syndrome (MDS)), at the 26th base (rs10925027, C or T) of the base sequence shown in SEQ ID NO: 1 of the NLRP3 gene of the donor or recipient Single nucleotide polymorphism, single nucleotide polymorphism in the 26th base (rs4621666, C or T) of the nucleotide sequence shown in SEQ ID NO: 2, or single nucleotide polymorphism in the relationship of linkage disequilibrium, and the original of the recipient Helps predict prognosis after transplantation using disease type as an indicator.