Method for determining resistance of cancer cells to epidermal growth factor receptor inhibitors

摘要

The present invention relates to a method for determining the resistance of a cancer cell to an EGFR inhibitor in a human patient suffering from cancer, the sample comprising the cancer cell collected from the human patient, A step of determining the presence or absence of a mutation in the 326th amino acid residue of the amino acid sequence of the B-Raf protein, and when the amino acid residue mutation is present, the cancer cell is resistant to an EGFR inhibitor; Provided is a method of determining that there is. According to such a method, cancer patients for whom treatment with an EGFR inhibitor is not effective can be selected in advance.