METHOD FOR DETERMINING TOLERANCE OF CANCER CELL TO EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR

摘要

The present invention provides a method for determining tolerance of a cancer cell to an EGFR inhibitor in a human patient suffering from a cancer, the method comprising a step of determining the presence or absence of a mutation of a 326th amino acid residue of an amino acid sequence of a B-Raf protein of the cancer cell by using a sample containing the cancer cell collected from the human patient, wherein the cancer cell is determined as tolerant to the epidermal growth factor receptor inhibitor, when the mutation of the amino acid residue is present. According to such a method, it is possible to select in advance a cancer patient for whom a treatment with the EGFR inhibitor is ineffective.