Novel crystal mixture of levonorgestrel and process for producing the same

摘要

A levonorgestrel crystal mixture comprising polymorphic levonorgestrel crystals α which give an X-ray powder diffraction spectrum that has diffraction peaks at the following diffraction angles (α) in terms of 2θ and polymorphic levonorgestrel crystals β which give an X-ray powder diffraction spectrum that has diffraction peaks at the following diffraction angles (β) in terms of 2θ. The ratio (by weight) of the polymorphic crystals α to the polymorphic crystals β, former/latter, may be 5/95 to 90/10. (α): 17.2°±0.2°, 18.6°±0.2°, 22.7°±0.2°, 31.1°±0.2°, and 35.5°±0.2° (β): 13.9°±0.2°, 14.5°±0.2°, 21.3°±0.2°, 24.9°±0.2°, and 28.2°±0.2° This levonorgestrel crystal mixture is useful as emergency contraceptive pills, etc.