Method for constructing quadrants with multiple independent biomarkers for diagnosing neurodegenerative diseases

摘要

The present invention relates to a method for constructing quadrants corresponding to different diseases in a frame of concentrations of multiple independent biomarkers, comprising:(a) transferring original distributed concentrations of every independent biomarker to modified distributed concentrations, comprising: calculating the mean value and the standard deviation of the original distributed concentrations for a given independent biomarker;individually subtracting all the original distributed concentrations by the mean value for the given independent biomarker; andindividually dividing all the differences by the standard deviation to get the modified distributed concentrations for the given independent biomarker;(b) positing the modified distributed concentrations in a frame of multiple independent biomarkers; and(c) finding a boundary optimally separating neighboring quadrants corresponding to different diseases.