Adenylyl cyclase inhibitors for chronic pain and opioid dependence

摘要

This present application disclosed a series of selective adenylyl cyclase 1 (AC1) inhibitors, compounds having a formula; or a pharmaceutically acceptable salt thereof, as a pain therapeutic. Those compounds may provide an effective method of treatment for chronic/inflammatory pain. Those compounds may also prevent opioid dependence and/or reduce opioid dependence. Both method and composition matters are within the scope of this invention.