; (b) converting the compound of (a) to a C1-C4 alkyl acetal;(c) subjecting the acetal to a trans-acetalization reaction with allyl alcohol in the presence of a mild acid catalyst;(d) heating the product of (c) in the presence of an acid catalyst to give an allylenolether; and(e) subjecting the product of (d) to a Claisen rearrangement to give spirogalbanone. ;The method affords an easier and more efficient method of preparation."/>
Process for preparing spirogalbanone
A method of making spirogalbanone includes the steps of:(a) subjecting ethynylspirodecanol to a Rupe rearrangement to give a compound of the formula I; (b) converting the compound of (a) to a C1-C4 alkyl acetal;(c) subjecting the acetal to a trans-acetalization reaction with allyl alcohol in the presence of a mild acid catalyst;(d) heating the product of (c) in the presence of an acid catalyst to give an allylenolether; and(e) subjecting the product of (d) to a Claisen rearrangement to give spirogalbanone. ;The method affords an easier and more efficient method of preparation.
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