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Lung model device for inhalation toxicity testing

机译:用于吸入毒性测试的肺模型装置

摘要

A lung model device for inhalation toxicity testing is provided. The device has a plurality of mesh tissue panels having lung cells attached thereto arranged inside a case so as to have a similar structure to a human lung, and air and nanoparticles are supplied into the case through a separate respiratory operating unit, thereby enabling inhalation toxicity testing on nanoparticles to be simply and conveniently performed in an indirect way by determining changes in the state of the lung cells without using real laboratory animals. The mesh tissue panels having a smaller lattice spacing size are sequentially positioned according to the nanoparticle inflow direction, thereby providing a structure similar to the structure of a real lung.
机译:提供了用于吸入毒性测试的肺部模型装置。该装置具有多个网状组织面板,所述多个网状组织面板具有附接到其上的肺细胞,所述多个网状组织面板布置在壳体内,以具有与人肺相似的结构,并且空气和纳米颗粒通过单独的呼吸操作单元被供应到壳体中,从而实现吸入毒性通过确定肺细胞状态的变化,无需使用真正的实验动物,就可以通过间接方式对纳米粒子进行简单而方便的测试。具有较小的晶格间隔尺寸的网状组织面板根据纳米颗粒的流入方向顺序地定位,从而提供与真实肺的结构相似的结构。

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