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ENCAPSULATION OF PHOSPHODIESTERASE INHIBITORS TO TREAT ALCOHOLIC LIVER DISEASE
ENCAPSULATION OF PHOSPHODIESTERASE INHIBITORS TO TREAT ALCOHOLIC LIVER DISEASE
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机译:磷酸酯酶抑制剂治疗酒精性肝病的研究
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摘要
Provided herein are compositions for treating liver inflammation. The compositions include a biologically active phosphodiesterase 4 (PDE4) inhibitor and a liposome, the liposome encapsulating the PDE4 inhibitor. The liposome may be anionic and include both neutrally charged and negatively charged phospholipids. Encapsulation of the PDE4 inhibitor in the liposome facilitates targeted delivery to the liver while limiting access to the central nervous system.
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