Ruthenium-catalyzed synthesis of biaryl compounds in water

摘要

Using a [RuCl₂(arene)]₂ complex and a formate source, a directed ortho C—H insertion and aryl-aryl coupling sequence in water provides biaryl compounds useful in the preparation of biologically active molecules and intermediates. Reactions may be conducted in the ambient atmosphere. Ruthenium catalysts prepared from [RuCl₂(arene)]₂ and a formate source may be prepared in situ or isolated for later use.