首页> 外国专利> METHOD FOR ONLINE SAMPLING AN ALIQUOT FROM A MOBILE PHASE COMPRISING AN ANALYTE OF AN APPARATUS FOR PRODUCING A PHARMACEUTICAL OR CHEMICAL PRODUCT

METHOD FOR ONLINE SAMPLING AN ALIQUOT FROM A MOBILE PHASE COMPRISING AN ANALYTE OF AN APPARATUS FOR PRODUCING A PHARMACEUTICAL OR CHEMICAL PRODUCT

机译：从包含制造待测药品的设备分析物的移动相中对样品进行在线采样的方法

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摘要

A method for online sampling an aliquot from a mobile phase comprising an analyte of an apparatus (102) for producing a pharmaceutical or chemical product, wherein the apparatus (102) comprises an analytical device (114) and a tube (112), wherein the tube (112) comprises an inlet (116), an outlet (118) and at least one curved portion (120), wherein the outlet (118) is in fluid communication with the analytical device (114), wherein the curved portion (120) is located between the inlet (116) and the outlet (118), wherein a flow direction of the mobile phase is defined from the inlet (116) to the outlet (118), the method comprising: providing a sample device (124) comprising a needle (134) with a needle tip (136), a septum (138) pierceable by the needle (134) and a pump (128), wherein the needle (134) is moveable between an extended position in which the septum (138) is pierced by the needle (134), and a retracted position, in which the septum (138) is not pierced, disposing the sample device (124) at the curved portion (120) of the tube (112), moving the needle (134) to the extended position such that the needle tip (136) faces the flow direction, and operating the pump (128) so as to draw an aliquot out of the mobile phase.;Further, a system (100) comprising an apparatus (102) for producing a pharmaceutical or chemical product and a sample device (124) is disclosed.

机译：一种从流动相在线采样等分试样的方法，该等分试样包含用于生产药品或化学产品的设备（ 102 ）的分析物，其中该设备（ 102 ）包括分析装置（ 114 ）和试管（ 112 ），其中试管（ 112 ）包括入口（ 116 ），出口（ 118 ）和至少一个弯曲部分（ 120 ），其中出口（ 118 ）与分析装置（ 114 ），其中弯曲部分（ 120 ）位于入口（ 116 ）和出口（ 118 ），其中从入口（ 116 ）到出口（ 118 ）定义了流动相的流动方向，该方法包括：样品设备（ 124 ），包括带有针尖（ 136 ）和隔垫（ 138 的针（ 134 ） >）可被针（ 134 ）和泵（ 128 ）刺穿，其中针（ 134 ）可在伸出的位置之间移动隔膜（ 138 ）被针（ 134 ）刺穿的位置以及缩回位置（ 138 ）的缩回位置未被刺穿，将样品装置（ 124 ）放置在试管（ 112 ）的弯曲部分（ 120 ）上，移动针头（ 134 ）移至伸出位置，以使针尖（ 136 ）面向流动方向，并操作泵（ 128 ），以使从流动相中提取等分试样。此外，系统（ 100 ）包括用于生产药品或化学产品的设备（ 102 ）和样品装置（< B> 124 ）。 展开▼

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公开/公告号US2019277730A1

专利类型

公开/公告日2019-09-12

原文格式PDF

申请/专利权人 HOFFMANN-LA ROCHE INC.;
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申请/专利号US201716461891

发明设计人 BENEDIKT SCHEIDECKER;REINHARD BRAAZ;JOSEF VINNEMEIER;AGATHE JUSTINE BALLIN;
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申请日2017-11-22

分类号G01N1/20;B01L3/02;

国家 US

入库时间 2022-08-21 12:13:52

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