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3-(6-alkoxy-5-chlorobenzoDisoxazol-3-YL)propanoic acid useful as kynurenine monooxygenase inhibitors
3-(6-alkoxy-5-chlorobenzoDisoxazol-3-YL)propanoic acid useful as kynurenine monooxygenase inhibitors
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机译:3-(6-烷氧基-5-氯苯并[D]异恶唑-3-基)丙酸可用作犬尿氨酸单加氧酶抑制剂
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摘要
The present invention relates to a compound of formula (I); or pharmaceutically acceptable salts thereof, which are Kynurenine monooxygenase (KMO) inhibitors, which are useful in the treatment of various disorders, which may include, but are not limited to, for diseases such as, for example: acute pancreatitis, chronic kidney disease, acute kidney disease, acute kidney injury, other conditions associated with systemic inflammatory response syndrome (SIRS), Huntington's disease, Alzheimer's disease, spinocerebellar ataxias, Parkinson's disease, AIDS-dementia complex, HIV infection, amylotrophic lateral sclerosis (ALS), depression, schizophrenia, sepsis, cardiovascular shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe burns, pneumonia, extensive surgical procedures, ischemic bowel, severe acute hepatic disease, severe acute hepatic encephalopathy or acute renal failure.
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