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Methods and apparatuses for estimating parameters in a predictive model for use in sequencing-by-synthesis
Methods and apparatuses for estimating parameters in a predictive model for use in sequencing-by-synthesis
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机译:在通过合成定序的预测模型中估计参数的方法和装置
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摘要
A method of estimating a parameter related to sequencing of a sample nucleic acid template includes: receiving signal data relating to nucleotide incorporation events resulting from a series of flows of nucleotides onto an array of wells including (i) a first well containing the sample nucleic acid template and (ii) a plurality of other sample-containing wells; determining sequence information for the sample nucleic acid template using signal data from the first well; and constructing a phase-state model for a set of nucleotide flows that contributed at least in part to the sequence information, wherein the model includes a signal correction parameter that is determined using signal data from the plurality of other sample-containing wells.
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