首页> 外国专利> Cosmetic composition for preventing or ameliorating hypersensitive skin comprising cedrol or derivatives thereof, or pharmaceutically acceptable salts thereof

Cosmetic composition for preventing or ameliorating hypersensitive skin comprising cedrol or derivatives thereof, or pharmaceutically acceptable salts thereof

机译:用于预防或改善过敏性皮肤的化妆品组合物,其包含雪松酚或其衍生物或其药学上可接受的盐

摘要

The present invention relates to a pharmaceutical composition for preventing or treating autoimmune diseases having cedrol or a pharmaceutically acceptable salt thereof as an active ingredient. Particularly, the cedrol or the derivative thereof of the present invention inhibits the expression of IL-17A, and in particular, cedrol, cedryl acetate, and cedrene exhibit the effect of delaying the outbreak of psoriasis and treating thereof in a psoriasis animal model. Therefore, these compounds can be used for the treatment of autoimmune diseases mediated by IL-17.
机译:本发明涉及用于预防或治疗自身免疫性疾病的药物组合物,该药物组合物以雪松酚或其药学上可接受的盐为有效成分。特别地,本发明的雪松酚或其衍生物抑制IL-17A的表达,特别地,在牛皮癣动物模型中,雪松酚,乙酸雪松菊酯和雪松烯具有延迟牛皮癣发作和治疗牛皮癣的作用。因此,这些化合物可用于治疗IL-17介导的自身免疫疾病。

著录项

  • 公开/公告号US10307383B2

    专利类型

  • 公开/公告日2019-06-04

    原文格式PDF

  • 申请/专利号US201815945601

  • 发明设计人 HA WON KIM;DONG HEE LEE;

    申请日2018-04-04

  • 分类号A61K31/045;A61K31/015;A61P17/06;A61P17/04;A61P37;A61K31/075;A61K31/12;A61K31/215;A61K31/336;

  • 国家 US

  • 入库时间 2022-08-21 12:13:01

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