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Sulfonamide compounds as voltage-gated sodium channel modulators

机译:磺酰胺化合物作为电压门控钠通道调节剂

摘要

The present invention relates to sulfonamide compounds Formula (I) wherein the substituents are as described herein, and their use in a medicine for the treatment of diseases, disorders associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. It further relates to the compounds herein and their pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof useful in treating diseases, disorders, syndromes and/or conditions associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. The invention also relates to process for the preparation of the compounds of the invention.; embedded image
机译:本发明涉及式(I)的磺酰胺化合物,其中取代基如本文所述,及其在用于治疗与抑制电压门控钠通道(VGSC)有关的疾病,病症,特别是Na Sub的药物中的用途V 1.7。它还涉及本文的化合物及其药学上可接受的盐,其药物组合物,可用于治疗与抑制电压门控钠通道(VGSC)特别是Na V 相关的疾病,病症,综合症和/或病症子> 1.7。本发明还涉及制备本发明化合物的方法。 “嵌入式图像”

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