Polymyxin derivatives and their use in combination therapy together with different antibiotics

摘要

Described are compounds of formula (I) for use in combination treatment with a second active agent, such as rifampicin, for example for treatment of a microbial infection. The compound of formula (I) is a polymyxin compound is:; where the groups -A-, —R¹, —R², —R³, —R⁴, —R⁵, —R⁶, —R⁷, —R⁸, and —X— are described in detail within the description.