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Antipsychotic injectable depot composition

机译:抗精神病注射剂组合物

摘要

The present invention is directed to a composition that can be used to deliver an antipsychotic drug such as risperidone as an injectable in-situ forming biodegradable implant for extended release providing therapeutic plasma levels from the first day. The composition is in the form of drug suspension on a biodegradable and biocompatible copolymer or copolymers solution using water miscible solvents that is administered in liquid form. Once the composition contacts the body fluids, the polymer matrix hardens retaining the drug, forming a solid or semisolid implant that releases the drug in a continuous manner. Therapeutic plasma levels of the drug can be achieved since the first day up to at least 14 days or more even up to at least four weeks.
机译:本发明涉及可用于递送抗精神病药物如利培酮的组合物,其作为可注射的原位形成的生物可降解的植入物用于延长释放,从第一天起提供治疗性血浆水平。该组合物是使用以水形式施用的与水混溶的溶剂在生物可降解和生物相容的共聚物或共聚物溶液上的药物悬浮液形式。一旦组合物接触体液,聚合物基质就会硬化并保留药物,形成固体或半固体植入物,以连续方式释放药物。从第一天起至少14天或更长时间甚至至少四个星期就可以达到药物的治疗性血浆水平。

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