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Glycopeptide for contrast agent targeting cancer cells and contrast agent kit containing the same
Glycopeptide for contrast agent targeting cancer cells and contrast agent kit containing the same
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机译:用于靶向癌细胞的造影剂的糖肽和包含该糖肽的造影剂试剂盒
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摘要
The present disclosure relates to a glycopeptide targeting cancer cells and a contrast agent kit containing the same. The glycopeptide is one wherein an azide reporting monosaccharide is bound to a substrate peptide. As the substrate peptide is specifically cleaved by cathepsin B in cancer cells, an azide reporting monosaccharide is expressed onto the cell surface via metabolic glycoengineering, thereby providing a target for action as a contrast agent. Accordingly, because the azide is exposed to the cell surface only by cathepsin B, as it is specifically expressed in cancer cells, in particular in metastatic cancer cells, while it is limitedly expressed in normal cells and is hardly excreted out the cells, the cancer cells can be selectively imaged by an azide-specific contrast agent.
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