A prediction system for grouping hepatocellular carcinoma includes an image capturing unit and a non-transitory machine readable medium. The non-transitory machine readable medium storing a program which, when executed by at least one processing unit, predicts a hepatocellular carcinoma group of the subject patient with hepatocellular carcinoma. The program includes a reference database obtaining module, a first image preprocessing module, a feature selecting module, a classifying module, a second image preprocessing module and a comparing module.
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