Pyrimidone Compounds Used as Lp-PLA2 Inhibitors and Pharmaceutical Compositions Thereof

摘要

The present invention relates to pyrimidone compounds used as Lp-PLA₂ inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R₁, R₂, R₃, X, Ar, Y and n are defined as in the specification and claims. The compounds of general formula (I) in the present invention, stereoisomers and pharmaceutically acceptable salts thereof can be used as Lp-PLA₂ inhibitors for preventing, treating and/or ameliorating diseases associated with the activity of Lp-PLA₂ enzyme.;