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METHOD OF DIFFERENTIATING NEURAL STEM CELLS OR NEURAL PRECURSOR CELLS INTO DOPAMINE NEURONS
METHOD OF DIFFERENTIATING NEURAL STEM CELLS OR NEURAL PRECURSOR CELLS INTO DOPAMINE NEURONS
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机译:将神经干细胞或神经前体细胞分化为多巴胺神经元的方法
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摘要
The present invention relates to a method of differentiating neural stem cells or neural precursor cells into dopamine neurons and more particularly, a method of differentiating into dopamine neurons, in which chromosomal stability is maintained by transfecting neural stem cells or neural precursor cells with mRNA of a dopamine neuron-inducing transcription factor under time-based control. The method of differentiating into dopamine neurons, according to the present invention, may enable preparation of mature and functional dopamine neurons having chromosomal stability by synthesizing a dopamine neuron-inducing transcription factor into a mRNA form, which has no risk of genetic modification, and transfecting the synthetic mRNA, unlike existing methods using retroviral vectors, and thus may be usefully used in the clinical field for the treatment of Parkinson's disease.
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