Dual-warhead covalent inhibitors of FGFR-4

摘要

The disclosure includes compounds of Formula (I); wherein Warhead1, Warhead2, R₃, R₄, R₅, R₆, R₇, R₈, Q, A, B, p, q, Z₁, Z₂, Z₃, and Z₄ are defined herein. Also disclosed is a method for treating a neoplastic disease with these compounds.