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Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells
Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells
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机译:具有免疫效应子活性并内在叶酸受体α阳性细胞中的抗体
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摘要
This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and have the ability in the alternative to become internalized by cells expressing folate receptor alpha (FRA) and to induce an immune effector activity such as antibody-dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to FRA-expressing cells as well as in eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to nucleotides encoding the antibodies of the invention, cells expressing the antibodies; methods of detecting cancer cells; and methods of treating cancer using the antibodies.
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