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APPARATUS AND METHODS FOR ESTIMATING AN ELECTRICAL STIMULATION EFFECT ON CORTICAL NEURONS
APPARATUS AND METHODS FOR ESTIMATING AN ELECTRICAL STIMULATION EFFECT ON CORTICAL NEURONS
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机译:用于估计对皮层神经的电刺激作用的装置和方法
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摘要
A method is disclosed for predicting the stimulation effect of cortical neurons in response to extracellular electrical stimulation. The method comprising the steps of defining an electrode configuration, defining a reconstructed neuronal cell type, wherein the reconstructed neuronal cell is characteristic of the physical and electrical properties of a neuronal cell, computing an electric field potential at the reconstructed neuronal cell, computing an effective transmembrane current of an arborization of the reconstructed neuronal cell, and determining a probability of activation of the reconstructed neuronal cell. A method for inducing an electrical stimulation effect on a cortical column is also disclosed. In an embodiment, the predicted network response of a cortical column is used to configure one or more electrodes to induce cortical stimulation.
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