HYPERAMMONEMIA THERAPY FOR CHILDREN SUFFERING FROM UREA CYCLE DISORDERS

摘要

A method and composition for treating or preventing the progression of hyperammonemia caused by a Urea Cycle Disorder, the method comprising administration of an effective amount of porous activated carbon particles, wherein the porous activated carbon particles are enteric-coated in order to control their release and adsorption properties. The porous activated carbon particles or microspheres can initially be coated with lactulose, followed by enterically coating the lactulose-covered carbon particles. The inventive method and composition provides a safe and uncomplicated reduction of ammonia levels in affected children.