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IMPROVED BLOOD-BRAIN BARRIER ENDOTHELIAL CELLS DERIVED FROM PLURIPOTENT STEM CELLS FOR BLOOD-BRAIN BARRIER MODELS

机译：从血脑干模型的多潜能干细胞获得的改良的血脑屏障内皮细胞

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摘要

The invention relates to a method of creating a human blood-brain barrier (BBB) model from the differentiation of human pluripotent stem cells (hPSCs), wherein the BBB exhibits sustained transendothelial electrical resistances (TEER) over 2000 Ω·cm²for at least 3 days after seeding.

机译：本发明涉及一种通过人多能干细胞（hPSC）的分化来创建人血脑屏障（BBB）模型的方法，其中所述BBB在2000Ω·cm Sup 2上表现出持续的跨内皮电阻（TEER）。播种后至少 3 天。 展开▼

著录项

公开/公告号US2019048316A1

专利类型

公开/公告日2019-02-14

原文格式PDF

申请/专利权人 PRESIDENT AND FELLOWS OF HARVARD COLLEGE;
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申请/专利号US201716076857

发明设计人 TAE-EUN PARK;ANNA HERLAND;EDWARD ANTHONY FITZGERALD;DONALD ELLIOT INGBER;
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申请日2017-02-16

分类号C12N5/071;G01N27/403;C12N5;

国家 US

入库时间 2022-08-21 12:08:29

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1. 用于限定条件下的人多潜能干细胞的血内皮分化的方法和材料 [P] . 中国专利： CN105209609B . 2020.08.21

2. 从小体积的外周血产生诱导性多潜能干细胞 [P] . 中国专利： CN103003416B . 2016.11.16

3. Improved blood-brain barrier endothelial cells derived from pluripotent stem cells for blood-brain barrier models [P] . 英国专利： GB2562940A . 2018-11-28

机译：改进的多能干细胞来源的血脑屏障内皮细胞用于血脑屏障模型

4. Improved blood-brain barrier endothelial cells derived from pluripotent stem cells for blood-brain barrier models [P] . 英国专利： GB201812258D0 . 2018-09-12

机译：改进的多能干细胞来源的血脑屏障内皮细胞用于血脑屏障模型

5. IMPROVED BLOOD-BRAIN BARRIER ENDOTHELIAL CELLS DERIVED FROM PLURIPOTENT STEM CELLS FOR BLOOD-BRAIN BARRIER MODELS [P] . SG11201806453TA . 2018-08-30

机译：从血脑干模型的多潜能干细胞获得的改良的血脑屏障内皮细胞

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