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PHARMACEUTICAL FORM FOR ORAL ADMINISTRATION OF A HIGHLY CONTROLLED AND STABLE DOSE OF NANOPARTICLES OR BIOMACROMOLECULE SUSPENSIONS
PHARMACEUTICAL FORM FOR ORAL ADMINISTRATION OF A HIGHLY CONTROLLED AND STABLE DOSE OF NANOPARTICLES OR BIOMACROMOLECULE SUSPENSIONS
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机译:高度控制和稳定剂量的纳米颗粒或生物大分子悬浮液的口服给药的药物制剂
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摘要
The invention relates to the pharmaceutical industry, particularly to the pharmaceutical industry related to drugs comprising biomacromolecules, or biopharmaceuticals. Even more particularly, the invention relates to a pharmaceutical form comprising biomacromolecules such as lymphokines, hormones, haematopoietic factors, growth factors, antibodies, enzymes, inhibitors, vaccines, and DNA or RNA derivatives. The invention provides a pharmaceutical form comprising biomacromolecules and a method for producing same based on inkjet printing using inks formed by nanosystems comprising the biomacromolecule(s), the drug or biopharmaceutical being administered orally. Even more particularly, the invention relates to a pharmaceutical form for oral administration of a highly controlled, stable controlled release dose of a biomacromolecule comprising: a) a polymer film as a printing substrate, formed by at least one pharmaceutically acceptable excipient; and b) an inkjet ink printed on the polymer film and comprising nanoparticles or nanoparticle suspensions comprising the biomacromolecule and at least one pharmaceutically acceptable excipient.
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