PRECATALYSTS AND PROCESS FOR THE METAL-FREE FUNCTIONALIZATION OF SP2 CARBONS USING THE SAME

摘要

Precatalysts and catalytic processes for the functionalization of sp²-carbons using the precatalysts are described herein. The precatalysts comprise an intramolecular Frustrated Lewis Pair (FLP) that is generated in situ from the corresponding precatalyst fluoroborate salts. The precatalyst fluoroborate salts are deprotected in situ to generate catalysts including intramolecular FLPs for the dehydrogenative borylation of alkenes, arenes and heteroarenes. The catalytic process comprises contacting a precatalyst, a functionalization reagent; and a substrate comprising a sp²-H carbon, under conditions to provide a substrate comprising a functionalized sp² carbon.