A METHOD OF IDENTIFYING AND GUIDING CORTICAL STIMULATION SITES FOR THE APPLICATION OF A FOCAL-NEUROMODULATION TECHNIQUE

摘要

A method for identifying at least one cortical stimulation site in a subject for the application as a target that can be used for treatment of a psychiatric/neurological disorder related to a deep brain region of the ventromedial prefrontal cortex including the subgenual and rostral anterior cingulate by using a first focal-neuromodulation technique, said method comprising:applying pulses of a second a focal-neuromodulation technique to different cortical areas of said subject;simultaneously with the application of said pulses at a cortical area measuring a psychophysiological signal representative of a heart rate of the subject for said cortical area, andwhen observing a systematic change in psychophysiological signal, identifying a corresponding cortical area as at least one cortical stimulation site that is functionally connected to said deep brain region of the ventromedial prefrontal cortex including the subgenual and rostral anterior cingulate for presenting said target for the treatment.