CORTICAL NEURON CELL MODEL OF ALZHEIMER'S DISEASE BASED ON BMI1 DEFICIENCY, AND USES THEREOF

摘要

The invention is concerned with dementia-related neurological diseases and more particularly Alzheimer's disease. Herein described are primate cortical neuronal cells that are BMI1 -deficient and that displays one or more phenotypic hallmark of Alzheimer's disease. Also described are cellular models comprising such cells, methods for screening, designing anti-Alzheimer drugs and/or for identifying a potential biological target of an anti-Alzheimer drug using such cells. Described also are methods for diagnosing Alzheimer's disease, comprising assessing BMI1 activity and/or comprising detecting epigenetic BMI1 silencing.