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Methods for Mass Spectrometric Based Characterization of Biological Molecules
Methods for Mass Spectrometric Based Characterization of Biological Molecules
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机译:基于质谱的生物分子表征方法
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摘要
Applications of ion-ion reaction chemistry are disclosed in which proton transfer reactions (PTR) combined with higher-collision-energy dissociation (HCD) are used to (1) simplify complex mixture analysis of samples introduced into a mass spectrometer, and (2) improve resolution and sensitivity for the analysis of large proteins in excess of 50 kDa by removing charge, reducing the collisional cross section, and, in several cases, enhancing the sequence coverage obtained.
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