USE OF CIRCULATING SERUM TROP-2 AS NEW TUMOR BIOMARKER

摘要

The present invention consists of a method for non-invasive monitoring of the presence of tumor disease in a patient, characterized by measuring the levels of the circulating Trop-2 protein in unfractionated serum obtained from the tumor patient. This method also allows non-invasive monitoring of tumor progression or regression, by comparing the levels of the Trop-2 biomarker measured in unfractionated serum samples taken at different times from the same patient. This method also allows the non-invasive monitoring of tumor response to therapy, wherein the levels of the Trop-2 biomarker are measured in unfractionated serum samples taken from the same patient before, during and after cancer therapy. It is part of the present invention a method for measuring the circulating Trop-2 protein in unfractionated serum.