首页> 外国专利> METHOD FOR PROGNOSING AND REDUCING CARDIOVASCULAR DISEASE IN PATIENTS WITH KIDNEY DISEASES

METHOD FOR PROGNOSING AND REDUCING CARDIOVASCULAR DISEASE IN PATIENTS WITH KIDNEY DISEASES

机译:肾脏疾病患者的心血管疾病预后和减少方法

摘要

The present invention discloses a method for prognosing and reducing cardiovascular diseases in patients with kidney diseases, comprising obtaining a bio-sample of a healthy person and a bio-sample of a patient with kidney disease, detecting the expression of specific lncRNA biomarkers individually, such as one or more combinations of DKFZP434I0714, KCNJ2AS1, LOC256880, LOC644656, FAM86FP, FAM66D, LOC100289511, and HTR7P1, comparing the expressions between the samples of the healthy persons and the samples of the patients with kidney diseases to obtain a ratio, and prognosing whether the patients with kidney diseases belong to a high-risk group to have cardiovascular diseases based on the ratio. Furthermore, the method reduces the possibility of patients with kidney diseases to have cardiovascular diseases through the inhibition technology.
机译:本发明公开了一种用于预测和减少患有肾脏疾病的患者的心血管疾病的方法,该方法包括:获得健康人的生物样品和患有肾脏疾病的患者的生物样品,分别检测特定的lncRNA生物标志物的表达,例如作为DKFZP434I0714,KCNJ2AS1,LOC256880,LOC644656,FAM86FP,FAM66D,LOC100289511和HTR7P1的一种或多种组合,比较健康人的样本与肾病患者的样本之间的表达以获得比率,并预测是否根据比例,肾病患者属于高危人群,患有心血管疾病。此外,该方法通过抑制技术降低了肾病患者患有心血管疾病的可能性。

著录项

  • 公开/公告号US2019127795A1

    专利类型

  • 公开/公告日2019-05-02

    原文格式PDF

  • 申请/专利权人 TIFFANY WU;CHI-HUA FOUNDATION;

    申请/专利号US201815926760

  • 发明设计人 WAN-LIN WU;

    申请日2018-03-20

  • 分类号C12Q1/6883;C12N15/113;

  • 国家 US

  • 入库时间 2022-08-21 12:06:25

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