COMPOSITIONS AND METHODS FOR SCREENING PEDIATRIC GLIOMAS AND METHODS OF TREATMENT THEREOF

摘要

The present invention provides methods for screening and diagnosing pediatric low-grade glioma (PLGG) based on a correlation between angiocentric glioma and MYB-QKI rearrangement. Specific methods for detecting the rearrangement encompass cytogenetic methods, DNA sequencing, RNA sequencing and antibody-based methods to detect the fusion protein. The disclosure also provides methods for treating PLGGs, especially angiocentric gliomas, by suppressing the expression or activity of MYB-QKI fusion gene