Various implementations include a Human Thermoregulation Simulator (HTRS) that simulates the natural and primary thermoregulatory functions of a patient that are relevant during therapeutic hypothermia procedures. For example, in various implementations, a HTRS includes a core container configured to be at least partially filled with water, and the core container includes a heat generator configured to heat the water inside the core container. A middle container is disposed concentrically around the core container, and the middle container includes a foam layer configured to be saturated by water. An outer container is disposed concentrically around the middle container, and the outer container includes a network of tubing disposed on at least a portion of an inner surface of the outer container. The HTRS also includes a pump configured to circulate water from the core container through the network of tubing.
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