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Prevention of Pertussis Using Adenylate Cyclase Deficient Bordetella Strains

机译：使用腺苷酸环化酶缺陷型博德氏杆菌预防百日咳

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摘要

A CyaA-deficient B. pertussis mutant was constructed and used in a vaccine. The pertussis-specific antibody profile and Th17 response induced by vaccination with the mutant was surprisingly comparable to that induced by B. pertussis strains not deficient in CyaA.

机译：缺乏CyaA的 B。构建了百日咳变种，并用于疫苗。突变疫苗接种诱导的百日咳特异性抗体谱和Th17应答与I B诱导的令人惊讶地相当。不缺乏CyaA的百日咳菌株。 展开▼

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公开/公告号US2018339035A1

专利类型

公开/公告日2018-11-29

原文格式PDF

申请/专利权人 NATIONAL UNIVERSITY OF SINGAPORE;INSTITUT PASTEUR DE LILLE;INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE (INSERM);
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申请/专利号US201816034209

发明设计人 CAMILLE LOCHT;SYLVIE CLAUDETTE ALONSO;RUI FEN ANNABELLE LIM;
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申请日2018-07-12

分类号A61K39/02;

国家 US

入库时间 2022-08-21 12:04:59

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