Composition comprising at least one protoberberine alkaloid and its method of manufacture

摘要

The present invention relates to a composition in the form of an extrudate comprising at least one protoberberine alkaloid as active ingredient and at least one polymer, said protoberberine alkaloid comprising at least a first amorphous phase and optionally a second crystalline phase. The present invention also relates to the method of manufacturing such a composition and its use.