'functionality that binds to an asymmetric contact interface of a tyrosine kinase (rtk) receptor, hybridoma, pharmaceutical composition, use of an effective amount of functionality, method for identifying functionality that binds to an asymmetric contact interface of a tyrosine kinase receptor (rtk), and small molecule '.

摘要

"functionality that binds to an asymmetric contact interface of a tyrosine kinase (rtk) receptor, hybridoma, pharmaceutical composition, use of an effective amount of functionality, method for identifying functionality that binds to an asymmetric contact interface of a tyrosine kinase receptor (rtk), and small molecule ". The present invention provides fractions that bind to the asymmetric contact interface of a tyrosine kinase receptor (rtk), wherein the fractions inhibit rtk ligand-induced trans-autophosphorylation. The present invention also provides methods of treating or preventing an rtk-associated disease and methods for identifying fractions that bind to an asymmetric contact interface of an rtk.