METHOD OF IDENTIFYING A CANCER INDIVIDUAL THAT IS PROBABLE TO BENEFIT FROM TREATMENT WITH A COMBINATION THERAPY WITH A RAF INHIBITOR AND A SECOND INHIBITOR AND A SECOND INHIBITOR FOR MANUFACTURING MANUFACTURING

摘要

methods of diagnosing and treating cancer in patients who have or develop resistance to early cancer therapy. A method of identifying an individual who has cancer who is likely to benefit from treatment with a combination therapy with a raf inhibitor and a second inhibitor is provided. A method of treating cancer in an individual in need thereof is also provided and includes administering to the individual an effective amount of a raf inhibitor and an effective amount of a second inhibitor, wherein the second inhibitor is a mek inhibitor, a craf inhibitor. a crk1 inhibitor or a tpl2 / cot inhibitor. A method of identifying a target kinase that confers resistance to a first inhibitor is also provided.