'method for improving the treatment effect in a patient suffering from gastric cancer, in vitro method, kit, use of an olignucleotide or polypetide, and use of bevacizumab'

摘要

"method for improving the treatment effect in a gastric cancer patient, in vitro method, kit, use of an oligonucleotide or polypeptide, and use of bevacizumab" are methods for enhancing the treatment effect in a patient suffering from gastric cancer gastric cancer, in particular stomach or gastroesophageal junction ("gej") adenocarcinoma, by treatment with bevacizumab (avastin®) in combination with a chemotherapy regimen by determining the level of neuropillin expression relative to a control level determined in patients suffering from gastric cancer, in particular, adenocarcinoma of the stomach or gastroesophageal junction ("gej"). The improved treatment effect may be improved general survival or improved progression-free survival. The present invention further provides methods for assessing a patient's sensitivity or responsiveness to bevacizumab (avastin®) in combination with a chemotherapy regimen by determining the level of neuropilin expression relative to a control level determined in patients suffering gastric cancer, in particular, adenocarcinoma of the stomach or gastroesophageal junction ("gej").