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directed evolution conduction methods, directed evolution conduction method of biological molecules and computer system.

机译:定向进化传导方法,生物分子定向进化传导方法和计算机系统。

摘要

The present invention provides methods for rapidly and efficiently searching biologically-related data space. More specifically, the present invention provides methods for identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The present invention also provides methods for modeling sequence-activity relationships, including but not limited to stepwise addition or subtraction techniques, Bayesian regression, ensemble regression and other methods. The present invention further provides digital systems and software for performing the methods provided herein.
机译:本发明提供了用于快速且有效地搜索生物相关数据空间的方法。更具体地,本发明提供了从复杂的生物分子文库或这类文库的集合中鉴定具有所需性质或最适合获得此类性质的生物分子的方法。本发明还提供了用于建模序列-活性关系的方法,包括但不限于逐步加法或减法技术,贝叶斯回归,系综回归和其他方法。本发明进一步提供了用于执行本文提供的方法的数字系统和软件。

著录项

  • 公开/公告号BR112015018454A2

    专利类型

  • 公开/公告日2018-12-04

    原文格式PDF

  • 申请/专利权人 CODEXIS INC;

    申请/专利号BR20151118454

  • 发明设计人 ALLAN GREGORY COPE;JOHN NICHOLAS AGARD;

    申请日2014-01-29

  • 分类号G01N33/50;

  • 国家 BR

  • 入库时间 2022-08-21 12:03:41

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