COMPOSITION AND METHOD OF PRODUCTION OF NANOPARTICULATED SYSTEMS FOR MODIFIED RELEASE OF BENZNIDAZOLE

摘要

The invention relates to the composition and method of preparing nanoparticulate systems for modified release of benznidazole (n-benzyl-2- (2-nitroimidazol-1-yl) acetamide), which are in the form of polymeric nanoparticles based on polymers such as methacrylic acid derivatives (eudragit® r100, e100), poly (lactic acid) (pla), poly (lactic-co-glycolic acid) (plga) or lipids, and may have the surface of the particles functionalized with cationic agents, sialic acid, cholesterol or other molecules. These systems obtained by the solvent displacement / nanoprecipitation and / or solvent evaporation emulsification method, in order to enable oral and / or parenteral administration, modifying the bioavailability of the drug in relation to the available forms of administration, being efficient for the treatment. in the chronic phase of Chagas disease that allows to overcome natural biological barriers, which act in directing the drug to the infected cells and / or the parasite.