hev mutated polypeptides and their use for anti-hev antibody count

摘要

The present invention relates to the hepatitis virus p-orf2 protein polypeptide and comprising at least amino acid sequence 394-660, numbered with respect to a 660 amino acid p-orf2 protein, in which the three cysteines at positions 627 630 and 638 have been mutated or, for a p-orf2 protein of different length, at least the amino acid sequence corresponding to amino acids 394-660 of the 660 amino acid p-orf2 protein, wherein the three cysteines at the three positions corresponding to positions 627, 630 and 638 of the 660 amino acid p-orf2 protein were mutated. It also refers to processes for determining the presence of humoral response or rate of antibodies directed against the p-orf2 protein using these polypeptides, as well as their use in the context of a hepatitis e virus infection. No drawings.