Nitric oxide synthase pathway modulation for oral health

摘要

pharmaceutical compositions and methods of treating or preventing diseases and conditions associated with or distinguished by at least one of xerostomia and periodontal disease are provided by modulation of the nitric oxide synthase pathway, as are animal models and methods of drug examination. . Such modulation may be achieved by administration of tetrahydrobiopterin (bh4) or its prodrugs and / or salts. xerostomia treatment and prevention may have the side effect of also preventing periodontitis, tooth decay, parotid gland enlargement, inflammation and cleft lip (chelitis), inflammation or ulcers of the lingual and buccal mucosa, oral candidiasis, salivary gland infection (sialadenitis), halitosis, and cracking and cracking of the oral mucosa.