VACCINE COMPOSITIONS UNDERSTANDING AN ATTENTED MUTANT ZIKA VIRUS

摘要

The present invention relates to vaccine compositions comprising an attenuated mutant Zika virus. mutations were introduced at very specific positions that nullify the n-glycosylation site in the protein and the epidemic strain, which will prevent the generation of autoantibodies responsible for guillain-barre syndrome. additional virus mutations have also been produced which result in a drastic reduction of cytopathic effects without affecting the ability to produce high virus titers. In particular, the present invention relates to an attenuated mutant Zika virus comprising a protein and an epidemic strain wherein at least one amino acid residue at position 152, 156 or 158 is mutated.