Method or process for the production of a glycoprotein, glycoprotein, use of a glycoprotein, treatment method, pharmaceutical preparation, use or method, cell for the heterologous expression of a glycoprotein

摘要

The present invention relates to a method or process for producing a glycoprotein which interacts with or acts as an erythropoietin receptor (epor) agonist whose glycoprotein has modified efficacy, wherein the method or process comprises heterologous expression. said glycoprotein in a suitable expression system, and wherein at least one step is provided which results in a reduced acetylation rate of sialic acid residues in the glycoprotein.