BIOLOGICAL NANOPOS FOR BIOPOLYMER DETECTION AND FRAGACEATOXIN C-ACTINOPORIN-BASED SEQUENCING

摘要

The invention generally relates to the field of nanopores and their use in various applications, such as biopolymer and macromolecule analysis, typically making electrical measurements during translocation through nanopores. A system is provided comprising a funnel-shaped protein nanopore comprising an α-helical pore forming toxin which is a member of the actinoporin protein family, more specifically fragaceatoxin c (frac), a frac mutant, a frac paralog or a homologue. weak